Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction
نویسندگان
چکیده
منابع مشابه
Smoking Modifies the Associated Increased Risk of Future Cardiovascular Disease by Genetic Variation on Chromosome 9p21
AIMS Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors. METHODS AND RESULTS A total of 24,944 middle-aged subjects (62% females) from the population-based Malmö-Diet-and-Cancer-...
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Several previous studies have investigated the role of common promoter variants in the vascular endothelial growth factor (VEGF) gene in causing congenital cardiovascular malformation (CVM). However, results have been discrepant between studies and no study to date has comprehensively characterised variation throughout the gene. We genotyped 771 CVM cases, of whom 595 had the outflow tract malf...
متن کاملValue of Chromosome 9p21 Polymorphism for Prediction of Cardiovascular Mortality in Han Chinese Without Coronary Lesions
Variants at chromosome 9p21 are associated with coronary artery disease (CAD). However, the longitudinal effects of 9p21 variants on cardiovascular mortality remain controversial and may depend on whether the patient has CAD. We tested the hypothesis that the single-nucleotide polymorphism (SNP) rs4977574 is associated longitudinally with cardiovascular death in patients without detectable coro...
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متن کاملChromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.
BACKGROUND rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. METHODS rs1333049 polymorphism was genotyped in 520 patients with a first acute MI ...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2013
ISSN: 0954-6820
DOI: 10.1111/joim.12063